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1.
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8 p, 1.2 MB |
An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD
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Taylor, Jonathan (Sheffield Teaching Hospitals NHS Foundation Trust) ;
Thomas, Richard (Sheffield Teaching Hospitals NHS Foundation Trust) ;
Metherall, Peter (Sheffield Teaching Hospitals NHS Foundation Trust) ;
van Gastel, Marieke (University Medical Centre Groningen) ;
Cornec-Le Gall, Emilie (University Brest) ;
Caroli, Anna (Istituto di Ricerche Farmacologiche Mario Negri IRCCS) ;
Furlano, Monica (Institut d'Investigació Biomèdica Sant Pau) ;
Demoulin, Nathalie (Cliniques Universitaires Saint-Luc) ;
Devuyst, Olivier (Cliniques Universitaires Saint-Luc) ;
Winterbottom, Jean (Sheffield Teaching Hospitals NHS Foundation Trust) ;
Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
Perico, Norberto (Istituto di Ricerche Farmacologiche Mario Negri IRCCS) ;
Le Meur, Yannick (University Brest) ;
Schoenherr, Sebastian (Medical University of Innsbruck) ;
Forer, Lukas (Medical University of Innsbruck) ;
Gansevoort, Ron T. (University Medical Centre Groningen) ;
Simms, Roslyn J. (Sheffield Teaching Hospitals NHS Foundation Trust) ;
Ong, Albert C. M. (Sheffield Teaching Hospitals NHS Foundation Trust) ;
Universitat Autònoma de Barcelona
Accurate tools to inform individual prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD) are lacking. Here, we report an artificial intelligence (AI)-generated method for routinely measuring total kidney volume (TKV). [...]
2023 -  10.1016/j.ekir.2023.10.029
Kidney International Reports, Vol. 9 (november 2023) , p. 249-256
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2.
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13 p, 1.1 MB |
Fractures in patients with CKD-diagnosis, treatment, and prevention : a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation
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Pimentel, Ana (Centro Hospitalar do Algarve) ;
Ureña-Torres, Pablo (University of Paris Descartes) ;
Zillikens, M. Carola (Erasmus MC Rotterdam) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Cohen-Solal, Martine (Hôpital Lariboisière) ;
Universitat Autònoma de Barcelona
Mineral and bone disease is omnipresent in patients with chronic kidney disease (CKD) and leads to a diverse range of clinical manifestations, including bone pain and fractures. The accumulation of traditional clinical risk factors, in addition to those related to CKD, enhances the risk of comorbidity and mortality. [...]
2017 - 10.1016/j.kint.2017.07.021
Kidney International, Vol. 92 Núm. 6 (december 2017) , p. 1343-1355
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3.
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15 p, 1.9 MB |
Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutations in UMOD and MUC1
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Olinger, Eric (Newcastle University) ;
Hofmann, Patrick (Hospital Uster) ;
Kidd, Kendrah (Charles University) ;
Dufour, Inès (Division of Nephrology. Cliniques Universitaires Saint-Luc) ;
Belge, Hendrica (Institute of Pathology and Genetics) ;
Schaeffer, Céline (San Raffaele Scientific Institute) ;
Kipp, Anne (University of Zurich) ;
Bonny, Olivier (Lausanne University Hospital) ;
Deltas, Constantinos (University of Cyprus) ;
Demoulin, Nathalie (Université catholique de Louvain) ;
Fehr, Thomas (Cantonal Hospital Graubuenden) ;
Fuster, Daniel G. (Inselspital Bern University Hospital) ;
Gale, Daniel (University College of London) ;
Goffin, Eric (Université catholique de Louvain) ;
Hodaňová, Kateřina (Charles University) ;
Huynh-Do, Uyen (Inselspital Bern University Hospital) ;
Kistler, Andreas (Cantonal Hospital Frauenfeld) ;
Morelle, Johann (Université catholique de Louvain) ;
Papagregoriou, Gregory (University of Cyprus) ;
Pirson, Yves (Cliniques Universitaires Saint-Luc) ;
Sandford, Richard (Cambridge Biomedical Campus) ;
Sayer, John (Newcastle University) ;
Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
Venzin, Christina (Hospital Davos) ;
Venzin, Reto (Cantonal Hospital Graubuenden) ;
Vogt, Bruno (Inselspital Bern University Hospital) ;
Živná, Martina (Charles University) ;
Greka, Anna (Massachusetts Institute of Technology) ;
Dahan, Karin (Institute of Pathology and Genetics) ;
Rampoldi, Luca (San Raffaele Scientific Institute) ;
Kmoch, Stanislav (Charles University) ;
Bleyer, Anthony (Charles University) ;
Devuyst, Olivier (Cliniques Universitaires Saint-Luc) ;
Universitat Autònoma de Barcelona
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of end-stage kidney disease, primarily due to mutations in UMOD and MUC1. The lack of clinical recognition and the small size of cohorts have slowed the understanding of disease ontology and development of diagnostic algorithms. [...]
2020 - 10.1016/j.kint.2020.04.038
Kidney International, Vol. 98 Núm. 3 (september 2020) , p. 717-731
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4.
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13 p, 1.6 MB |
Refining Kidney Survival in 383 Genetically Characterized Patients With Nephronophthisis
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König, Jens Christian (Department of General Pediatrics, University Children's Hospital Münster) ;
Karsay, Rebeka (Department of General Pediatrics, University Children's Hospital Münster) ;
Gerß, Joachim (Institute of Biostatistics and Clinical Research, University of Münster) ;
Schlingmann, Karl-Peter (Department of General Pediatrics, University Children's Hospital Münster) ;
Dahmer-Heath, Mareike (Department of General Pediatrics, University Children's Hospital Münster) ;
Telgmann, Anna-Katharina (Department of General Pediatrics, University Children's Hospital Münster) ;
Kollmann, Sabine (Department of General Pediatrics, University Children's Hospital Münster) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Gillion, Valentine (Division of Nephrology, Saint-Luc Academic Hospital, Université Catholique Louvain) ;
Bockenhauer, Detlef (Great Ormond Street Hospital for Children (Londres)) ;
Bertholet-Thomas, Aurélia (Centre de Référence des Maladies Rénales Rares-Néphrogones-Hôpital Femme Mère Enfant, Hospices Civils de Lyon-Filière ORKiD) ;
Mastrangelo, Antonio (Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico) ;
Boyer, Olivia (Hôpital Necker-Enfants Malades, Université de Paris) ;
Lilien, Marc (Department of Pediatric Nephrology, University Medical Center Utrecht) ;
Decramer, Stéphane (Université Toulouse III Paul-Sabatier) ;
Schanstra, Joost. P. (Université Toulouse III Paul-Sabatier) ;
Pohl, Martin (Department of Pediatrics, University Hospital Freiburg) ;
Schild, Raphael (University Medical Center Hamburg-Eppendorf) ;
Weber, Stefanie (University Children's Hospital) ;
Hoefele, Julia (Institut für Humangenetik) ;
Drube, Jens (Departement of Pediatric Nephrology, Medical School Hannover) ;
Cetiner, Metin (Department of Pediatric Nephrology, University of Duisburg-Essen) ;
Hansen, Matthias (Clementine Kinderhospital) ;
Thumfart, Julia (Charité - Universitätsmedizin Berlin) ;
Tönshoff, Burkhard (Department of Pediatrics I, University Children's Hospital Heidelberg) ;
Habbig, Sandra (Department of Pediatric, University of Cologne) ;
Liebau, Max Christoph (University Hospital Cologne and Medical) ;
Bald, Martin (Children's Hospital (Alemanya)) ;
Bergmann, Carsten (Medizinische Genetik Mainz (Alemanya)) ;
Pennekamp, Petra (Department of General Pediatrics, University Children's Hospital Münster) ;
Konrad, Martin (Department of General Pediatrics, University Children's Hospital Münster) ;
Universitat Autònoma de Barcelona
Nephronophthisis (NPH) comprises a group of rare disorders accounting for up to 10% of end-stage kidney disease (ESKD) in children. Prediction of kidney prognosis poses a major challenge. We assessed differences in kidney survival, impact of variant type, and the association of clinical characteristics with declining kidney function. [...]
2022 - 10.1016/j.ekir.2022.05.035
Kidney International Reports, Vol. 7 (june 2022) , p. 2016-2028
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5.
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16 p, 1.1 MB |
Genetics in chronic kidney disease : conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
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Köttgen, Anna (Institute of Genetic Epidemiology. Faculty of Medicine and Medical Center. University of Freiburg) ;
Cornec-Le Gall, Emilie (Univ Brest. INSERM UMR 1078. GGB. CHU Brest) ;
Halbritter, Jan (Charité - Universitätsmedizin Berlin) ;
Kiryluk, Krzysztof (Division of Nephrology and Center for Precision Medicine and Genomics. Department of Medicine. Columbia University Irving Medical Center) ;
Mallett, Andrew (KidGen Collaborative. Australian Genomics Health Alliance) ;
Parekh, Rulan (Dalla Lana School of Public Health. and Health Policy. Management and Evaluation. University of Toronto) ;
Rasouly, Hila Milo (Division of Nephrology and Center for Precision Medicine and Genomics. Department of Medicine. Columbia University Irving Medical Center) ;
Sampson, Matthew G. (Kidney Disease Initiative. Broad Institute of MIT and Harvard) ;
Tin, Adrienne (Division of Nephrology. University of Mississippi Medical Center) ;
Antignac, Corinne (Department of Genetics. Necker Hospital. APHP) ;
Ars, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ;
Bergmann, Carsten (Department of Nephrology. Faculty of Medicine and Medical Center. University of Freiburg) ;
Bleyer, Anthony J. (Section on Nephrology. Wake Forest School of Medicine) ;
Bockenhauer, Detlef (Department of Renal Medicine. University College London) ;
Devuyst, Olivier (Department of Physiology. Mechanisms of Inherited Kidney Disorders Group. University of Zurich) ;
Florez, Jose C. (Department of Medicine. Harvard Medical School) ;
Fowler, Kevin J. (The Voice of the Patient. Inc.) ;
Franceschini, Nora (Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina) ;
Fukagawa, Masafumi (Division of Nephrology. Endocrinology and Metabolism. Tokai University School of Medicine) ;
Gale, Daniel (Rare Renal Disease Registry. UK Renal Registry) ;
Gbadegesin, Rasheed A. (Department of Pediatrics. Division of Nephrology. Duke University Medical Center) ;
Goldstein, David B. (Department of Genetics and Development. Columbia University) ;
Grams, Morgan E. (Department of Nephrology. Johns Hopkins University School of Medicine) ;
Greka, Anna (Department of Medicine. Brigham and Women's Hospital. Harvard Medical School) ;
Gross, Oliver (University Medical Center Göttingen) ;
Guay-Woodford, Lisa M. (Center for Translational Science. Children's National Health System) ;
Harris, Peter C. (Division of Nephrology and Hypertension. Mayo Clinic) ;
Hoefele, Julia (Technische Universität München. Institut für Humangenetik) ;
Hung, Adriana M. (VA Tennessee Valley Healthcare System. Division of Nephrology and Hypertension. Department of Medicine. Vanderbilt Center for Kidney Disease. Vanderbilt Precision Nephrology Program. Vanderbilt University Medical Center) ;
Knoers, Nine V.A.M. (Department of Genetics. University Medical Center Groningen) ;
Kopp, Jeffrey B. (Kidney Disease Section. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). National Institutes of Health (NIH)) ;
Kretzler, Matthias (Department of Computational Medicine and Bioinformatics. University of Michigan) ;
Lanktree, Matthew B. (Department of Medicine. McMaster University) ;
Lipska-Ziętkiewicz, Beata S. (Rare Diseases Centre and Clinical Genetics Unit. Department of Biology and Medical Genetics. Medical University of Gdansk) ;
Nicholls, Kathleen (Department of Nephrology. Royal Melbourne Hospital. University of Melbourne) ;
Nozu, Kandai (Department of Pediatrics. Kobe University Graduate School of Medicine) ;
Ojo, Akinlolu (University of Kansas School of Medicine) ;
Parsa, Afshin (Department of Medicine. University of Maryland School of Medicine) ;
Pattaro, Cristian (Eurac Research. Institute for Biomedicine (affiliated with the University of Lübeck)) ;
Pei, York (Division of Nephrology. University Health Network) ;
Pollak, Martin R. (Division of Nephrology. Beth Israel Deaconess Medical Center. Harvard Medical School) ;
Rhee, Eugene P. (Massachusetts General Hospital) ;
Sanna-Cherchi, Simone (Columbia University) ;
Savige, Judy (The University of Melbourne) ;
Sayer, John (NIHR Newcastle Biomedical Research Centre) ;
Scolari, Francesco (Department of Medical and Surgical Specialties. University of Brescia) ;
Sedor, John R. (Case Western Reserve University. Department of Physiology and Biophysics) ;
Sim, Xueling (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ;
Somlo, Stefan (Yale University. Department of Genetics) ;
Susztak, Katalin (University of Pennsylvania. Perelman School of Medicine) ;
Tayo, Bamidele O. (Loyola University Chicago. Department of Public Health Sciences) ;
Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
van Eerde, Albertien M. (Utrecht University Medical Center. Department of Genetics) ;
Weinstock, André (Alport Syndrome Foundation) ;
Winkler, Cheryl A. (Frederick National Laboratory for Cancer Research. National Cancer Institute) ;
Wuttke, Matthias (University of Freiburg) ;
Zhang, Hong (Key Ministry of Health of China. Laboratory of Renal Disease) ;
King, Jennifer M. (August Editorial) ;
Cheung, Michael (KDIGO) ;
Jadoul, Michel (Université Catholique de Louvain. Cliniques Universitaires Saint Luc) ;
Winkelmayer, Wolfgang C. (Baylor College of Medicine. Selzman Institute for Kidney Health) ;
Gharavi, Ali G. (Columbia University Irving Medical Center) ;
Universitat Autònoma de Barcelona
Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as well as genes for complex kidney diseases that manifest in combination with environmental factors, have been discovered. [...]
2022 - 10.1016/j.kint.2022.03.019
Kidney International, Vol. 101 Núm. 6 (june 2022) , p. 1126-1141
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6.
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13 p, 1.4 MB |
The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy
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Fernández-Juárez, Gema (Hospital Universitario Fundación Alcorcón) ;
Rojas-Rivera, Jorge E. (Hospital Universitario Fundación Jiménez Díaz) ;
Logt, Anne-Els van de (Radboud University Medical Center) ;
Justino, Joana (Université Côte d'Azur. Institut de Pharmacologie Moléculaire et Cellulaire (Valbonne, França)) ;
Sevillano Prieto, Angel Manuel (Hospital Universitario 12 de Octubre (Madrid)) ;
Caravaca-Fontan, Fernando (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Ávila, Ana (Hospital Universitari Doctor Peset (València)) ;
Rabasco, Cristina (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Cabello, Virginia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Varela, Alfonso (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Díaz Encarnación, Montserrat Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Martín-Reyes, Guillermo (Hospital Regional Universitario de Málaga) ;
Goicoechea, Marian (Hospital General Universitario Gregorio Marañón) ;
Quintana, Luis F. (Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud) ;
Agraz Pamplona, Irene (Hospital Universitari Vall d'Hebron) ;
Gómez-Martino, Juan Ramón (Hospital San Pedro de Alcántara) ;
Cao, Mercedes (Complejo Hospitalario Universitario de A Coruña) ;
Rodríguez-Moreno, Antolina (Hospital Clínico San Carlos (Madrid)) ;
Rivas, Begoña (Hospital Universitario La Paz (Madrid)) ;
Galeano Alvarez, Cristina (Hospital Universitario Ramón y Cajal (Madrid)) ;
Bonet, Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romera, Ana (Hospital General de Ciudad Real) ;
Shabaka, Amir (Hospital Universitario Fundación Alcorcón) ;
Plaisier, Emmanuelle (Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique (Niça, França)) ;
Espinosa, Mario (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Egido de los Rios, Jesus (Hospital Universitario Fundación Jiménez Díaz) ;
Segarra-Medrano, Alfonso (Hospital Universitari Vall d'Hebron) ;
Lambeau, Gérard (Institut de Pharmacologie Moléculaire et Cellulaire (Valbonne, França)) ;
Ronco, Pierre (Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique (Niça, França)) ;
Wetzels, Jack (Radboud University Medical Center) ;
Praga, Manuel (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Caravaca-Fontan, Fernando (Hospital Universitario 12 de Octubre (Madrid)) ;
Trujillo, Hernando (Hospital Universitario 12 de Octubre (Madrid)) ;
Gutiérrez, Eduardo (Hospital Universitario 12 de Octubre (Madrid)) ;
Ortiz, Alberto (Hospital Universitario Fundación Jiménez Díaz) ;
Goicoechea, Marian (Hospital General Universitario Gregorio Marañón) ;
Verdalles, Úrsula (Hospital General Universitario Gregorio Marañón) ;
Segarra, Alfons (Hospital Universitari Vall d'Hebron) ;
Perea, Lara (Hospital Universitari Vall d'Hebron) ;
Valera, Ildefonso (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Martín, Mónica (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Pérez Valdivia, Miguel Angel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Blasco, Miquel Angel (Hospital Clínic i Provincial de Barcelona) ;
López Muñiz, Andrés (Complejo Hospitalario Universitario de A Coruña) ;
Malek, Tamara (Hospital Universitari Doctor Peset (València)) ;
DaSilva Santos, Iara ;
Bonet, Jordi (Institut Germans Trias i Pujol) ;
Navarro, Maruja Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Huerta, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rodríguez-Paternina, Ezequiel (Hospital Universitario de Getafe (Madrid)) ;
Vigil, Ana (Hospital Universitario Severo Ochoa) ;
Alcázar, Roberto (Hospital Universitario Infanta Leonor) ;
Paraíso, Vicente (Hospital Universitario del Henares ( Madrid)) ;
Barrio, Vicente (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Hofstra, Julia (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persistent remission in these patients. [...]
2021 - 10.1016/j.kint.2020.10.014
Kidney International, Vol. 99 Núm. 4 (april 2021) , p. 986-998
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13 p, 1.8 MB |
The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment
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Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Dixon, B.P. (Renal Section. Department of Pediatrics. University of Colorado School of Medicine) ;
Kim, S.H. (Department of Pediatrics. Pusan National University Children's Hospital) ;
Kapur, G. (Faculty of Pediatric Sciences. Central Michigan University. Mount Pleasant) ;
Mauch, T. (Department of Nephrology and Hypertension. Division of Pediatrics. University of Utah) ;
Ortiz, S. (Clinical and Non-Clinical Pharmacology. Alexion Pharmaceuticals Inc.) ;
Vallee, M. (Biostatistics. Alexion Pharmaceuticals Inc.) ;
Denker, A.E. (Clinical Development. Alexion Pharmaceuticals Inc.) ;
Kang, H.G. (Division of Pediatric Nephrology. Department of Pediatrics. Seoul National University College of Medicine) ;
Greenbaum, L.A. (Division of Pediatric Nephrology. Emory University School of Medicine and Children's Healthcare of Atlanta) ;
Lovell, H. ;
Muff-Luett, M. ;
Malone, K. ;
Adeagbo, O. ;
Wilkerson, A. ;
Fraga Rodríguez, Gloria María (Institut d'Investigació Biomèdica Sant Pau) ;
Sarri, S. ;
Cheong, H.I. ;
Ahn, Y.H. ;
Han, K.H.
Ravulizumab, a long-acting complement C5 inhibitor engineered from eculizumab, allows extending maintenance dosing from every 2-3 weeks to every 4-8 weeks depending on bodyweight. Here, we evaluated the efficacy and safety of ravulizumab in complement inhibitor-naïve children (under 18 years) with atypical hemolytic uremic syndrome. [...]
2021 - 10.1016/j.kint.2020.10.046
Kidney International, Vol. 100 Núm. 1 (july 2021) , p. 225-237
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11 p, 703.6 KB |
Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
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Buxeda, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arias Cabrales, Carlos E (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Sáez, María josé (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cacho, Judit (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cabello Pelegrin, Sheila (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Melilli, Edoardo (Hospital Universitari de Bellvitge) ;
Aladrén, María José (Hospital Universitario Miguel Servet (Saragossa)) ;
Galeano Alvarez, Cristina (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Lorenzo, Iinmaculada (Complejo Hospitalario Universitario de Albacete) ;
Mazuecos, Auxiliadora (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Saura, Isabel María (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Franco, Antonio (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Ruiz-Fuentes, María del Carmen. (Hospital Universitario Virgen de las Nieves (Granada)) ;
Sánchez-Cámara, Luis Alberto (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Siverio, Orlando (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Martin, María Luisa (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
González-García, Elena (Hospital Universitario La Paz (Madrid)) ;
López, Verónica (Instituto de Investigación Biomédica de Málaga) ;
Martin-Moreno, Paloma Leticia (Instituto de Investigación Sanitaria de Navarra) ;
Moina, Iñigo (Hospital de Basurto (Bilbao, Biscaia)) ;
Moral Berrio, Esperanza (Hospital General Universitario de Ciudad Real) ;
Moreso, Francesc (Hospital Universitari Vall d'Hebron) ;
Portolés, José María (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Santana-Estupiñán, Raquel (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Zárraga, Sofía (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Canal Girol, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Álvarez, Emilio (Hospital Universitario de Cabueñes (Gijón)) ;
Pascual, Julio (Pascual Santos) (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crespo, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. [...]
2021 - 10.1016/j.ekir.2021.06.023
Kidney International Reports, Vol. 6 Núm. 9 (september 2021) , p. 2305-2315
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9.
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10.
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11 p, 1.4 MB |
Hepatic Lactate Dehydrogenase A : An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
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Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Barrios, Kelly (Dicerna Pharmaceuticals, Inc., Lexington) ;
Brown, Bob D. (Dicerna Pharmaceuticals, Inc., Lexington) ;
Hoppe, Bernd (German Hyperoxaluria Center Cologne/Bonn) ;
Rosskamp, Ralf (Dicerna Pharmaceuticals, Inc., Lexington) ;
Langman, Craig B. (Ann and Robert H. Lurie Children's Hospital of Chicago) ;
Universitat Autònoma de Barcelona
Primary hyperoxaluria (PH) is a family of 3 rare genetic disorders of hepatic glyoxylate metabolism that lead to overproduction and increased renal excretion of oxalate resulting in progressive renal damage. [...]
2021 - 10.1016/j.ekir.2021.01.029
Kidney International Reports, Vol. 6 (february 2021) , p. 1088-1098
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